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Week 10 NFL odds: Bills vs. Patriots

The Patriots are well-rested and facing one of the worst defenses in the NFL, resulting in a likely double-digit spread in Week 10.

Kevin Hoffman-US PRESSWIRE

The New England Patriots start their second-half march this week with their annual home date against the Buffalo Bills. The Pats should be relatively rested and healthy, enjoying the Bye Week after their London blowout of the Rams.

In their first meeting of the season, the Patriots faced the Bills at an early crossroads of their 2012 campaign. After two straight losses, the Pats wiped out the Bills in upstate New York with a second-half offensive flurry. Their 31 fourth-quarter points delivered a resounding 52-28 thumping of what then appeared to be a AFC East contender.

Now, they'll get the Bills on home turf in Foxborough and they'll likely be favored by double digits. The spread opened with New England favored by 9½ points, and that shot up pretty early in the week to double digits. The line has gone up more than a point to at least 11 in most places and even to 12 in others. A well-rested home team against a stumbling Bills squad that has one of the worst defenses in the league clearly has the public on the side of the Pats. It also means a high over/under, which was set at 51.