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NFL Odds Week 2: Cardinals Vs. Patriots

The New England Patriots are heavy favorites to win against the Arizona Cardinals, with oddsmakers expecting a two-touchdown margin of victory.

The Cardinals might be 1-0, but there's no reason to expect them to be able to compete with New England. It's unclear whether John Skelton will be making the start after suffering an injury in Sunday's win over the Seattle Seahawks, although his backup Kevin Kolb is the one who threw a late touchdown pass to give the team a 20-16 victory. And the shaky quarterback situation is a bright spot: Beanie Wells only managed 14 yards for the Cards, putting the starting running back second in rushing to Andre Roberts, a wide receiver who had one carry for 15 yards. Bill Belichick's defense is probably salivating at the prospect of feasting on Arizona after scoring as many touchdowns as they allowed from the Tennessee Titans offense in Week 1.

The mismatch between one of the league's best and a squad that will struggle to manage in the NFC West led to a gaudy line featuring the Patriots favored by 14 points -- the biggest margin in the league.

Here's the lines heading into Sunday's matchup:

Opening line: New England -13

Current line: New England -14

Money lines: New England -900, Arizona +650

Over/under: 48

For more on the Patriots, head over to Pats Pulpit and continue to check out SB Nation Boston.