Bruins forward Tyler Seguin opened up the scoring, netting his 28th goal of the season just 3:15 into the second frame. He took a fancy pass from linemate Patrice Bergeron through the slot and he tapped it in past Jhonas Enroth to give the B's a 1-0 lead.
That lasted for half of the period, until the Sabres came back and wristed a rebound over Tim Thomas, courtesy of Brad Boyes, for his seventh goal of the year.
Thomas has made 16 stops through two periods, while Enroth has picked up 22 saves in his effort tonight.
Boston didn't let up until the very last second in the period though, and, even though they were on the penalty kill, forward Rich Peverley nearly picked up a shorthanded goal, finding himself on a breakaway and a lot of speed. Enroth eventually stopped him, but it was a positive way for the B's to head into the locker room.
Zdeno Chara was the reason for the shorthanded play, getting called for tripping with less than two minutes to go in the second. The Sabres will start the third with the extra man for 1:17.