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Week 4 NFL picks and predictions: Patriots Vs. Bills

The New England Patriots are favored in mid-week predictions to defeat the Buffalo Bills in Week 4.

Jim Rogash - Getty Images

Heading into Week 4, the New England Patriots claim a losing record for the first time since the beginning of the 2003 season. Fresh off consecutive last-second losses (one of which was far more controversial than the other), the team sits at 1-2 and shares ownership of last place in the AFC East standings with the Miami Dolphins.

On Sunday afternoon, New England will look to return to their accustomed winning ways when they travel to Buffalo for their first divisional matchup of the 2012 season against the Bills.

Buffalo will enter the game riding a two-game winning streak. After being dominated by the New York Jets in Week 1, the Bills have managed to hold their opponents to under 17 points over the last two weeks. In addition, running back Fred Jackson is expected to return to action even though C.J. Spiller has already been ruled out.

In terms of predictions, the experts over at ESPN have (to this point at least), unanimously predicted that the Patriots will be victorious. At CBS they are less certain but still have the Patriots as the favorites by a six-to-three margin.