Brady, fresh from agreeing on Thursday to a four-year contract extension reportedly worth $72 million, was an efficient 25-of-35 for 258 yards for the Patriots, who are coming off a 10-6 season and first-round playoff loss in 2009.
Coming off a season-ending torn ACL, Wes Welker struck for eight catches for 64 yards and two-first half scores. Randy Moss added five receptions for 59 yards and Fred Taylor gained 71 yards on 14 carries.
Chad Ochocinco led all receivers with 12 catches for 159 yards and a score. Terrell Owens made his Cincinnati regular-season debut by hauling in seven balls for 53 yards while Cedric Benson totaled 43 yards and a rushing TD on 15 attempts.