Vin Mazzaro (1-0) allowed nine hits and three runs over 3 1/3 relief innings for the win. Starter Brett Anderson left after two innings with left-elbow soreness after giving up five hits and two runs in two frames.
Bill Hall went 4-for-5 with a homer, two RBI and scored four times for the Red Sox, who saw their four-game win streak halted. Jeremy Hermida went 3-for-5 with a two-run homer and Marco Scutaro drove in three in a losing cause.
Tim Wakefield (1-4) allowed eight hits and six runs over six innings to take the loss.