The Baltimore Ravens -- 4-1 and atop the AFC North -- visit the New England Patriots -- 3-1, second in the AFC East -- in a battle of two NFL heavyweights, and a rematch of last season's Wild Card Game.
In that contest, the Ravens stormed Gillette Field and rush for 234 yards en route to a lopsided 33-14 win.
SB Nation's Joel Thorman calls it the game of the week in his preview of Week 6's action:
Breakdown: The game of the week in my mind. You've got the fourth ranked defense in the Ravens facing the No. 1 offense in the NFL in the Patriots. Tom Brady and Co. always have a hard time against the Ravens, as evidenced by the beating they received in the playoffs last year. This game will be all about how the Ravens defense can handle the Patriots offense.
Player to Watch: Deion Branch. Will he play Sunday? He's back on the Patriots after being traded a few years ago. The Patriots don't have Randy Moss so we're eager to see what that Patriots receiving group looks like.
Thorman's pick: take the Patriots at home.