New England is coming off a beating of the Buffalo Bills in which it put up 31 fourth-quarter points en route to a 52-28 victory. On the other hand, the Broncos looked sharp as ever by pummeling the Oakland Raiders 38-6 at home last Sunday.
It will be the first time in two years that Tom Brady and Manning face each other. The last matchup took place back on Nov. 21, 2010, which the Patriots won 31-28 at Gillette Stadium.
Another game to watch is a Keystone State affair, with the 3-1 Philadelphia Eagles and 1-2 Pittsburgh Steelers. Head coach Mike Tomlin says he expects Troy Polamalu and James Harrison to be available in this almost must-win for the black and gold.
Other contests to keep an eye on are the Bills traveling to take on the San Francisco 49ers and the Sunday night game, which features the winless New Orleans Saints playing host to the San Diego Chargers.