The Red Sox jumped out to an early 3-0 lead behind the bat of Jarrod Saltalamacchia. In the top of the second inning, the catcher hit a three-run homer, scoring first baseman Adrian Gonzalez and designated hitter Cody Ross.
The Blue Jays responded in the top of the third inning, when third baseman Brett Lawrie hit a sacrifice fly that scored second baseman Kelly Johnson. But Red Sox starting pitcher Aaron Cook regained his composure, making it out of the inning and allowing no runs in the fourth or fifth.
In the sixth inning, however, Toronto struck again, tying the game at 3-3 after a two-run shot by first baseman Edwin Encarnacion. An inning later, the Blue Jays took control of the game, tacking on three more runs to go up 6-3. The Blue Jays added another run in the top of the ninth when Rajai Davis scored off a fielder's choice. Aaron Cook was pulled after 6.1 innings, allowing five runs (three earned) on four hits. He took the loss to fall to 2-3 overall.
The Red Sox mustered five hits in the game, three of which came in the second inning when Boston put up three runs.
The loss drops Boston to 48-47 on the season, while Toronto improves to 47-47. Shortly before the start of the game, Boston honored former catcher Jason Varitek with a video tribute showing his highlights with the team.
The final game of the series between the Red Sox and Blue Jays will be played Sunday at 1:35 p.m. Eastern Time.