The Red Sox will aim for a series win Wednesday afternoon as Jon Lester takes the mound against the Blue Jays. First pitch is at 12:37 p.m. EST with broadcasts on NESN and WEEI.

After having the lineup go quiet behind him in the season opener against the Tigers, Lester will be hoping for some backup, both in the form of the runs they failed to produce last Thursday, and hopefully some defense that they failed to produce on Tuesday for Daniel Bard.

With lefty Ricky Romero taking the mound for the Blue Jays, the Red Sox will turn to their right-handed hitters in the outfield and behind the plate.

Boston Red Sox (1-4)

1. Jacoby Ellsbury, CF
2. Dustin Pedroia, 2B
3. Adrian Gonzalez, 1B
4. Kevin Youkilis, 3B
5. David Ortiz, DH
6. Darnell McDonald, RF
7. Cody Ross, LF
8. Mike Aviles, SS
9. Kelly Shoppach, C