Going for their second win in a row, the Red Sox will send Clay Buchholz to the mound. The native Texan has struggled lately, allowing at least three earned runs in each of his last five starts. He is currently 11-6 with a 4.46 ERA.
The Blue Jays will counter with Carlos Villanueva, who began the year as a reliever before becoming a starter in late June. Villanueva has made two starts against the Red Sox this season, allowing three earned runs each time.
A win would bring Boston into a tie with Toronto for fourth place in the AL East.
Saturday's game will start at 1:07 p.m. ET, and can be found on NESN.