It will be the first time that the Patriots get a look at Andrew Luck, who has the Colts at 6-3 and fighting for a playoff spot in the AFC. Luck was expected to be great, but not too many expected this kind of play so early from the rookie.
Tom Brady is no slouch however, and he's ready and waiting against a Colts defense that is formidable but not elite. New England is also 6-3 and leading the AFC East as its fights for a bye in the AFC Playoffs.
Other games to watch this week include the two primetime games on Sunday and Monday. The former has the Baltimore Ravens and Pittsburgh Steelers clashing at Heinz Field. Steelers quarterback Ben Roethlisberger will miss the game with a shoulder injury he suffered Monday night against the Kansas City Chiefs.
The complete NFL schedule for Week 11 is as follows. All times listed are Eastern.
Thursday, Nov. 15
Sunday, Nov. 18
Cincinnati Bengals at Kansas City Chiefs, 1 p.m., CBS
Indianapolis Colts at New England Patriots, 4:25 p.m., CBS
Baltimore Ravens at Pittsburgh Steelers, 8:20 p.m., NBC
Monday, Nov. 19
Chicago Bears at San Francisco 49ers, 8:30 p.m.